C₂₆₀H₃₈₇N₇₀O₇₄ · 5704.45 g/mol
FOXO4-DRI
FOXO4-DRI is a 49-amino-acid retro-inverso peptide designed to disrupt the interaction between the transcription factor FOXO4 and p53 in senescent cells. Senescent cells accumulate with age and secrete pro-inflammatory factors (SASP) that have been linked in research to age-related tissue dysfunction. By selectively triggering apoptosis in senescent cells while sparing healthy ones, FOXO4-DRI represents one of the most-studied targeted senolytic peptides in the longevity research field. Originally published in Cell in 2017 by Peter de Keizer's group.
Research Areas
- •Senolytic activity
- •FOXO4-p53 interaction
- •Senescent cell clearance
- •SASP modulation
- •Longevity pathways
Molecular Specifications
Molecular Formula
C₂₆₀H₃₈₇N₇₀O₇₄
Molecular Weight
5704.45 g/mol
Purity
≥98.0%
Select Size
Prices are subject to change. Final pricing will be confirmed at checkout.
Certificates of Analysis
Current batch test results for FOXO4-DRI. Click any row to download the full lab report PDF — third-party HPLC, USP<85> endotoxin, and USP<71> microbial testing.
| Size | Batch | Test Date | Purity | Endotox | Sterility | |
|---|---|---|---|---|---|---|
| 12mg | PC-J-FOX0 | 11/10/2025 | 99.48% | Pass | — | View PDF |
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